MovDisordV3, Main, Exploration, bibRecord, 001139

Dopamine Transporter Imaging in Autopsy-Confirmed Parkinson's Disease and Multiple System Atrophy

Identifieur interne : 001139 ( Main/Exploration ); précédent : 001138; suivant : 001140

Dopamine Transporter Imaging in Autopsy-Confirmed Parkinson's Disease and Multiple System Atrophy

Auteurs : Laura D. Perju-Dumbrava [Autriche] ; Gabor G. Kovacs [Autriche] ; Susanne Pirker [Autriche] ; Kurt Jellinger [Autriche] ; Martha Hoffmann [Autriche] ; Susanne Asenbaum [Autriche] ; Walter Pirker [Autriche]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0106490

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Atrophie multisystématisée, Dégénérescence, Pathologie du système nerveux, Dopamine, Autopsie, Tomoscintigraphie émission monophotonique.

English descriptors

KwdEn :
- Autopsy, Degeneration, Dopamine, Multiple system atrophy, Nervous system diseases, Parkinson disease, Single photon emission tomography.

Abstract

Dopamine transporter single-photon emission computerized tomography can visualize dopaminergic degeneration in Parkinson's disease and multiple system atrophy. Some studies have suggested that dopamine transporter imaging can distinguish these disorders based on a more diffuse and symmetric striatal dopamine transporter binding loss in multiple system atrophy. The present study compared patterns of striatal dopamine transporter distribution in postmortem-confirmed Parkinson's disease and multiple system atrophy. Patients with a postmortem diagnosis of multiple system atrophy (n = 6) or Parkinson's disease (n = 8) who had undergone dopamine transporter imaging were included. Imaging had been performed after a mean disease duration of 3.6 and 4.1 years in multiple system atrophy and Parkinson's disease, respectively. Visual analysis showed bilaterally reduced binding in all patients. Mean overall striatal binding was reduced by 53% in multiple system atrophy and 52% in Parkinson's disease. There was a trend for greater asymmetry of striatal binding in multiple system atrophy compared with Parkinson's disease (23% ± 15% vs 10.5% ± 7%, respectively; P = .071), with 3 multiple system atrophy patients showing more asymmetry of striatal binding than any Parkinson's disease patient. Putamen/caudate binding ratios did not differ between the groups. This is the first study comparing dopamine transporter imaging in autopsy-confirmed multiple system atrophy and Parkinson's disease. Unexpectedly, we found a tendency for greater asymmetry of striatal binding in multiple system atrophy than in Parkinson's disease. Our findings demonstrate that these conditions cannot be differentiated by subregional analysis of striatal dopamine transporter binding.

Affiliations:

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Le document en format XML

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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autopsy</term>
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<front><div type="abstract" xml:lang="en">Dopamine transporter single-photon emission computerized tomography can visualize dopaminergic degeneration in Parkinson's disease and multiple system atrophy. Some studies have suggested that dopamine transporter imaging can distinguish these disorders based on a more diffuse and symmetric striatal dopamine transporter binding loss in multiple system atrophy. The present study compared patterns of striatal dopamine transporter distribution in postmortem-confirmed Parkinson's disease and multiple system atrophy. Patients with a postmortem diagnosis of multiple system atrophy (n = 6) or Parkinson's disease (n = 8) who had undergone dopamine transporter imaging were included. Imaging had been performed after a mean disease duration of 3.6 and 4.1 years in multiple system atrophy and Parkinson's disease, respectively. Visual analysis showed bilaterally reduced binding in all patients. Mean overall striatal binding was reduced by 53% in multiple system atrophy and 52% in Parkinson's disease. There was a trend for greater asymmetry of striatal binding in multiple system atrophy compared with Parkinson's disease (23% ± 15% vs 10.5% ± 7%, respectively; P = .071), with 3 multiple system atrophy patients showing more asymmetry of striatal binding than any Parkinson's disease patient. Putamen/caudate binding ratios did not differ between the groups. This is the first study comparing dopamine transporter imaging in autopsy-confirmed multiple system atrophy and Parkinson's disease. Unexpectedly, we found a tendency for greater asymmetry of striatal binding in multiple system atrophy than in Parkinson's disease. Our findings demonstrate that these conditions cannot be differentiated by subregional analysis of striatal dopamine transporter binding.</div>
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<name sortKey="Kovacs, Gabor G" sort="Kovacs, Gabor G" uniqKey="Kovacs G" first="Gabor G." last="Kovacs">Gabor G. Kovacs</name>
<name sortKey="Perju Dumbrava, Laura D" sort="Perju Dumbrava, Laura D" uniqKey="Perju Dumbrava L" first="Laura D." last="Perju-Dumbrava">Laura D. Perju-Dumbrava</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Dopamine Transporter Imaging in Autopsy-Confirmed Parkinson's Disease and Multiple System Atrophy

Dopamine Transporter Imaging in Autopsy-Confirmed Parkinson's Disease and Multiple System Atrophy

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri